What is a specific disadvantage of Individual Micro-Isolator™ cages?

Individual Micro-Isolator™ cages are designed to provide a controlled environment for laboratory animals while preventing contamination from outside sources. One specific disadvantage of these cages is that air exchange may be reduced. This is due to the fact that the design aims to create a barrier that limits airflow to minimize the risk of pathogens entering the cage. While it is critical for maintaining sterility, the reduction in air exchange can lead to inadequate ventilation, which may impact the health and well-being of the animals housed within these cages.

In a laboratory setting, proper ventilation is important for removing harmful gases, providing fresh air, and ensuring a stable environment. Therefore, while the primary purpose of micro-isolator cages is to protect the animals from outside contamination, the trade-off can be reduced air exchange, which becomes a significant concern for long-term animal care. This is an important concept in understanding the balance between biosecurity and the needs of laboratory animals.