What is the primary focus of co-isogenic animals in research?

The primary focus of co-isogenic animals in research is to examine the effects of a single manipulated gene. Co-isogenic animals are genetically identical except for the specific gene that has been altered, which allows researchers to isolate and study the effects of that one genetic change in detail. This is particularly valuable in genetic and biomedical research, as it enables scientists to draw clearer conclusions about how a single gene influences phenotypic traits or disease processes without the confounding variables that genetic differences might introduce. Such a targeted approach is crucial for understanding gene function, enabling advancements in therapies and treatments related to genetic conditions.

In this context, co-isogenic animals are specifically used to explore the consequences of genetic manipulations, such as inserting, deleting, or modifying a gene, making them an essential tool in gene-focused studies.